Researcher in synthetic biology and biosynthetic gene cluster expression
NTNU - Norwegian University of Science and Technology
Høgskoleringen 1, 7491 Trondheim
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Stillingsbeskrivelse
Researcher in synthetic biology and biosynthetic gene cluster expression
We have a vacancy for a full-time three-year researcher at the Department of Biotechnology and Food Science, NTNU. The position is linked to AIMARIA – Accelerating Innovation in Marine AI-Powered Bioprospecting, a Horizon Europe Innovation Action coordinated by NTNU.
AIMARIA combines omics, bioinformatics, artificial intelligence, synthetic biology, bioprocess development and sustainability assessment to accelerate the discovery and sustainable production of marine and aquatic natural products. The researcher will have a leading role in developing NTNU's experimental platform for BGC expression.
Duties of the position
- Develop and implement strategies for the design, refactoring and heterologous expression of biosynthetic gene clusters.
- Design and construct expression systems, including promoters, 5′ untranslated regions and other regulatory DNA elements.
- Engineer and evaluate microbial host strains for the expression of complex biosynthetic pathways.
- Analyse and interpret molecular, expression and production data.
- Coordinate relevant NTNU activities with partners in the AIMARIA consortium.
- Contribute to project deliverables, scientific reports, presentations and peer-reviewed publications.
Krav
- A completed PhD in synthetic biology, molecular biology, biotechnology, microbiology, biochemistry, biochemical engineering or another relevant discipline.
- Documented hands-on experience in BGC refactoring, molecular cloning, DNA assembly and genetic engineering of microorganisms.
- Experience with heterologous gene expression, metabolic engineering, pathway engineering or related microbial biotechnology.
- Ability to plan, conduct, document and analyse experimental research independently.
- Excellent written and oral English language skills.
Ferdigheter
Synthetic biologyMolecular biologyMicrobial strain engineeringBGC refactoringDNA assemblyHeterologous gene expressionMetabolic engineeringBioinformatics
Erfaring
mid-level