Research position: urine-derived liquid biopsy in pediatric cancer

Research position: urine-derived liquid biopsy in pediatric cancer

A 2-year 100% scientist position with possibility of elongation for a highly motivated and skilled researcher is available at the Department of Pediatric Research, OUS Rikshospitalet on a project funded by the Norwegian Cancer Society.

Liquid biopsies leverage circulating molecular structures from body fluids, facilitating a less invasive yet more comprehensive diagnostic approach. Especially for childhood cancer patients it is crucial to obtain temporal and spatial insights that capture the tumor's heterogeneity and evolving structure over time. Peripheral blood is the common source for liquid biopsies; however, in childhood cancer patients, the sample volume is often restricted. In contrast, urine-derived samples are both abundant and harmless. Furthermore, recent technological advances allow for genomic, transcriptomic, proteomic, metabolomic, and methylation profiling using urine.

We will employ state-of-the-art analytical methods to gain deeper insights into the frequency and composition of cfDNA, the cargo and targets of EVs, and the expression and characteristics of circRNAs. Investigating urine-derived liquid biopsies will enhance our understanding of pediatric cancer biology, thereby contributing to improved diagnostic, monitoring, and therapeutic strategies for these vulnerable patients.

Working tasks:

• Conduct scientific research within the field of liquid biopsy in pediatric cancer and participate in developing the project.
• Perform laboratory work, including exploring the frequency and composition of cfDNA, discovering the cargo and targets of EVs, and investigating the distribution and characteristics of circulating circRNA in childhood cancer.
• Analyze and interpret genomic, transcriptomic, and proteomic data.
• Present research findings at national and international conferences.
• Contribute to scientific publications in peer-reviewed journals.
• Be part of writing new applications in the field of childhood cancer research.
• Participate in research group meetings and collaborative activities.